From MELVYL@UCCMVSA.UCOP.EDU Fri Feb 7 13:16:42 1997 Date: Mon, 22 Jan 96 22:01:55 PST From: Melvyl System Subject: (id: RDE23972) MELVYL system mail result Search request: F KW ZINC PYRITHIONE Search result: 12 citations in the Medline database Display: 1 2 9 11 12 1. Ermolayeva E; Sanders D. Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Applied and Environmental Microbiology, 1995 Sep, 61(9):3385-90. Type D 1 AB to see abstract. (UI: 96035671) AT: UCSF Library W1 AP 498 Journals 31-58, 1976-92 (PE title: Applied and environmental microbiology.) 2. Janniger CK; Schwartz RA. Seborrheic dermatitis. American Family Physician, 1995 Jul, 52(1):149-55, 159-60. Pub type: Journal Article; Review; Review, Tutorial. Type D 2 AB to see abstract. (UI: 95328483) AT: UCSF Library W1 AM 397 Journals 3, 1971- (PE title: American Family Physician (1971- )) 9. Lansdown AB. Interspecies variations in response to topical application of selected zinc compounds. Food and Chemical Toxicology, 1991 Jan, 29(1):57-64. Type D 9 AB to see abstract. (UI: 91153738) AT: UCSF Library W1 FO 403 Journals 20, 1982- (PE title: Food and chemical toxicology.) 11. Van Cutsem J; Van Gerven F; Fransen J; Schrooten P; Janssen PA. The in vitro antifungal activity of ketoconazole, zinc pyrithione, and selenium sulfide against Pityrosporum and their efficacy as a shampoo in the treatment of experimental pityrosporosis in guinea pigs. Journal of the American Academy of Dermatology, 1990 Jun, 22(6 Pt 1):993-8. Type D 11 AB to see abstract. (UI: 90317147) AT: UCSF Library W1 JO 2J Journals 1, 1979- UCSF Mt. Zion Journals v. 1, 1979- (PE title: Journal of the American Academy of Dermatology.) 12. Nakajima K; Yasuda T; Nakazawa H. High-performance liquid chromatographic determination of zinc pyrithione in antidandruff preparations based on copper chelate formation. Journal of Chromatography, 1990 Mar 2, 502(2):379-84. Type D 12 AB to see abstract. (UI: 90256975) AT: UCSF Library W1 JO 5845 Journals 1-651, 1958-93 (PE title: Journal of chromatography.) From MELVYL@UCCMVSA.UCOP.EDU Fri Feb 7 13:16:42 1997 Date: Mon, 22 Jan 96 22:41:07 PST From: Melvyl System Subject: (id: AQY24182) MELVYL system mail result Search request: F KW CELERY AND KW SKIN Search result: 12 citations in the Medline database Display: ABS 3 4 3. Poljacki M; Paravina M; Jovanovic M; Subotic M; Duran V. [Contact allergic dermatitis caused by plants]. Medicinski Pregled, 1993, 46(9-10):371-5. Language: Serbo-Croatian. (UI: 95089756) (Check for locations using F PE .) Abstract: In order to contribute to the setting of an accurate diagnosis and prophylaxis of phytodermatitis (PD) and to better understand eczematogenic characteristics of some plants, we present results of an allergologic analysis and review the plants which most commonly cause FD in our material. A total of 15 patients presenting with FD was examined. In all the cases we used a standard technique, patch test (PT); in cases supsective of contact urticaria syndrome (CUS) we used open PT, while photo PT was used for cases suspective of photo PD. We used fresh parts of the plants and standard allergen battery for epicutaneous testing (Department of Immunology, Zagreb). Depending on the profession of the subjects, tests with the material from working places with specific batteries of tests for specific professions were applied according to the recommendations of ICDRG. Tests with parts of the plants were carried out in 8 cases and in 5 controls. A total of 38 plants was examined. Positive PT was found for sisal, willow, parsnip, carrot, celery, spinach, green tomato, broomcorn, lemon skin, pyracantha, arborvitae, yucca, ficus, juniper tree, plane tree and greenhouse grass. In cases of positive PT for willow, carrot, celery, green tomato and grass, positive PT for Peru balsam (PB) was also detected, while in positive PT for lemon skin, a positive PT on turpentine was found as well. Negative results of PT for willow, carrot, celery, parsnip, green tomato, lemon and juniper tree and positive photo PT on greenhouse grass in controls, indicate that we have detected allergic PD on the above mentioned plants. 4. Finkelstein E; Afek U; Gross E; Aharoni N; Rosenberg L; Halevy S. An outbreak of phytophotodermatitis due to celery. International Journal of Dermatology, 1994 Feb, 33(2):116-8. (UI: 94208989) AT: UCSF Library W1 IN 766G Journals 9, 1970- (PE title: International journal of dermatology.) Abstract: BACKGROUND. Celery is known to contain psoralens, a group of substances that cause a toxic dermal reaction on exposure to ultraviolet A rays (UVA). An outbreak of phytophotodermatitis amongst 11 workers in a celery harvest in southern Israel is reported. METHODS. Analysis of the trigger factors was carried out. The patients were questioned regarding their working conditions. Samples of the celery that the workers had been harvesting were analyzed for levels of total psoralens by means of high performance liquid chromatography (HPLC). Levels of UVA were measured. RESULTS. It was found that the celery harvested in the south of the country contained 84 micrograms/g fresh weight (f.wt.) total psoralens as compared to 35 micrograms/g f.wt. in celery harvested in the north of the country at the same time. The following year the celery harvested in the south contained only 26 micrograms/g f.wt. total psoralens. Other risk factors noted were that the subjects had fair skin, wore no protective clothing, and worked with moist hands. In addition, the days were clear and sunny thus ensuring maximal UV radiation for that time of the year. CONCLUSIONS. Multiple factors contributed to the outbreak of phytophotodermatitis. A late harvest in the south of the country is incriminated as the cause of the unusually high levels of psoralens in the celery of that year. From MELVYL@UCCMVSA.UCOP.EDU Fri Feb 7 13:16:42 1997 Date: Mon, 22 Jan 96 22:42:21 PST From: Melvyl System Subject: (id: DGX24191) ZINC AND PSORIASIS Search request: F KW ZINC AND PSORIASIS Search result: 13 citations in the Medline database Display: ABS 2 3 6 11 2. Lontz W; Sirsjo A; Liu W; Lindberg M; Rollman O; Torma H. Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha. Free Radical Biology and Medicine, 1995 Feb, 18(2):349-55. (UI: 95262974) AT: UCSF Library W1 FR 598 Journals 4, 1988- (PE title: Free radical biology & medicine.) Abstract: Because reactive oxygen species have been implicated in the pathogenesis of various hyperproliferative and inflammatory diseases, the mRNA expression of the antioxidant enzyme superoxide dismutase was studied in psoriatic skin tissue. By using reverse transcription-PCR we found similar expression of copper, zinc superoxide dismutase (CuZnSOD) in the involved vs. uninvolved psoriatic skin. In contrast, the level of the manganese superoxide dismutase (MnSOD) mRNA message was consistently higher in lesional psoriatic skin as compared to adjacent uninvolved skin and healthy control skin. Parallel investigation of those cytokines that are thought to be direct or indirect inducers of the MnSOD activity revealed an increased mRNA expression of IL-1 beta, TNF-alpha, and GM-CSF in lesional psoriatic skin. To study if these cytokines exert a direct effect on dismutase expression in epidermal cells, human keratinocytes in culture were challenged with IL-1 beta, TNF-alpha, and GM-CSF. It was found that IL-1 beta and TNF-alpha, but not GM-CSF, induced the mRNA expression of MnSOD, and an additive effect was demonstrated for the two former cytokines. Further, the expression of both CuZnSOD and MnSOD transcripts was similar in cultured keratinocytes maintained at low differentiation (low Ca2+ medium) and cells forced to terminal differentiation (by high Ca2+ medium). Our results indicate that the abnormal expression of MnSOD mRNA in lesional psoriatic skin is not directly linked to the pathologic state of keratinocyte differentiation in the skin. It seems more likely that the cutaneous overexpression of MnSOD in psoriatic epidermis represents a protective cellular response evoked by cytokines released from inflammatory cells invading the diseased skin. 3. Burrows NP; Turnbull AJ; Punchard NA; Thompson RP; Jones RR. A trial of oral zinc supplementation in psoriasis. Cutis, 1994 Aug, 54(2):117-8. Pub type: Clinical Trial; Journal Article; Randomized Controlled Trial. (UI: 95044402) AT: UCSF Library W1 CU 97 Journals 1, 1965- (PE title: Cutis.) Abstract: A controlled double-blind study of oral zinc supplementation was performed in twenty-five patients with chronic plaque psoriasis over twelve weeks to assess changes in both psoriasis (using the psoriasis area and severity index) and neutrophil zinc content. There were no statistically significant differences in the psoriasis area and severity index during the trial between the placebo- and zinc-treated group, nor in the zinc levels. There was therefore no evidence of a benefit from zinc supplementation in patients with this disease. 6. Tasaki M; Hanada K; Hashimoto I. Analyses of serum copper and zinc levels and copper/zinc ratios in skin diseases. Journal of Dermatology, 1993 Jan, 20(1):21-4. (UI: 93246504) AT: UCSF Library W1 JO 619R Journals 1-18, 1974-91 (PE title: The Journal of dermatology.) Abstract: With the objective of comprehending abnormal metabolisms of the essential metals of zinc (Zn) and copper (Cu) in three groups of skin diseases, skin cancer, inflammatory diseases, and non-inflammatory disease, we measured serum levels of Zn and Cu in 151 cases of various cutaneous manifestations and estimated the significance of the ratios between the two metals (Cu/Zn). The serum level of Zn was significantly decreased in cases of bullous pemphigoid, decubitus ulcer, and alopecia areata. The serum level of Cu was elevated in cases of psoriasis, decubitus ulcer, and skin cancer. We observed no elevation of serum Zn level or abnormally depressed serum Cu level. The Cu/Zn ratio showed significantly different values among these three groups of the diseases, suggesting the utility of measuring Cu/Zn ratios for differential diagnosis over that of determining the serum level of Zn or Cu alone. It was also demonstrated that, in each skin disease, the Cu/Zn ratio clearly reflects the severity of the progress. 11. Leibovici V; Statter M; Weinrauch L; Tzfoni E; Matzner Y. Effect of zinc therapy on neutrophil chemotaxis in psoriasis. Israel Journal of Medical Sciences, 1990 Jun, 26(6):306-9. (UI: 90337711) AT: UCSF Library W1 IS 63TU Journals 1, 1965- (PE title: Israel journal of medical sciences.) Abstract: Neutrophil chemotaxis in patients with psoriasis vulgaris and psoriatic arthritis was investigated before and after 6 weeks of treatment with zinc sulphate (50 mg elementary zinc three times daily). In patients with active psoriasis vulgaris, a significant increase in neutrophil random migration and directed chemotaxis was demonstrated (10.2 +/- 3.1 and 14.1 +/- 4.1 mu, respectively, greater than that of control patients), while in patients with psoriatic arthritis the values were within the normal range (5.8 +/- 3.2 and 1.1 +/- 4.1 mu, respectively, greater than that of control patients). Although the zinc sulphate treatment had little or no effect on the course of either disease, it restored both the random migration and directed chemotaxis to normal values in psoriasis vulgaris patients. These results support the contention that zinc sulphate modifies neutrophil inflammatory potential; however, the lack of a clinical benefit suggests that neutrophils play only a secondary role in the pathogenesis of psoriasis. Date: Tue, 21 May 1996 04:23:09 -0700 From: Ed Anderson Subject: &r=7&f=G&key=83148734 Record from database: MEDLINE Title The inhibitory effect of zinc pyrithione on the epidermal proliferation of animal skins. Author Imokawa G, Okamoto K Source Acta Derm Venereol, 62: 6, 1982, 471-5 Abstract The hypothesis that zinc pyrithione, a highly active anti-dandruff agent, exerts an anti-biosynthetic effect and reduces the epidermal turnover has been tested using guinea pig and hairless mouse skins. It has been found that enhanced mitosis caused by both stripping off the horny layers and sodium dodecyl sulphate, could be suppressed by approximately 50% by the topical application of zinc pyrithione. Furthermore, sodium dodecyl sulphate-induced epidermal hyperproliferation has been found suppressible by the simultaneous application of zinc pyrithione. Thymidine incorporation studies using hairless mice revealed that a single application of zinc pyrithione results in reduction of DNA synthesis. It is suggested that the anti-dandruff effect of zinc pyrithione results primarily from its action as an anti-biosynthetic agent rather than from its anti-yeast action. Language of Publication English Unique Identifier 83148734 MeSH Heading (Major) Epidermis [CY/*DE/PH] Pyridines [*PD] MeSH Heading Animal DNA [BI] Guinea Pigs Mice Mice, Inbred HRS Mitosis [DE] Publication Type JOURNAL ARTICLE ISSN 0001-5555 Country of Publication SWEDEN CAS Registry/EC Number 0 (Pyridines) 13463-41-7 (zinc pyrithione) 9007-49-2 (DNA) Date: Tue, 21 May 1996 04:27:11 -0700 From: Ed Anderson Subject: &r=9&f=G&key=80239245 Record from database: MEDLINE Title Effects of pyrithiones and surfactants on zinc and enzyme levels in rabbits. Author Spiker RC Jr, Ciuchta HP Source Am Ind Hyg Assoc J, 41: 4, 1980 Apr, 248-52 Abstract The effects of zinc pyrithione (ZnPT) and sodium pyrithione (NaPT), including the influence of various vehicles, upon whole blood and plasma zinc levels and serum alkaline phosphatase (SAP) have been investigated in rabbits following dermal and/or iv administration. Two such vehicles, ammonium lauryl sulfate (ALS) and triethanolamine lauryl sulfate, affected zinc homeostasis differently than the pyrithiones, in that, unlike the pyrithiones, no whole blood changes were observed, although there were delayed and sustained declines in plasma zinc and SAP values. These changes were most likely related to the skin irritation caused by the surfactants. In contrast, NaPT-dimethyl sulfoxide (DMSO) dermal and iv exposures produced rapid decreases in plasma zinc followed by quick recovery, coupled with smaller and unsustained declines in SAP. Large increases in whole blood zinc were also observed in both cases, as well as in a ZnPT-DMSO iv exposure. DMSO itself had no effects on the measured parameters. Experiments involving combinations of the pyrithiones and ALS demonstrated effects on zinc homeostasis that were attributable to both substances, i.e. large increases in whole blood zinc (PT effect), quick drops in plasma zinc (PT effect) and slowly recovering plasma zinc and SAP values (surfactant effect). The chelating nature of the PT molecule may have been responsible for some of the observed changes in zinc distribution. Language of Publication English Unique Identifier 80239245 MeSH Heading (Major) Alkaline Phosphatase [*BL] Dimethyl Sulfoxide [*AD] Fatty Alcohols [*AA] Pyridines [*AD] Skin Absorption [*DE] Zinc [*BL] MeSH Heading Administration, Topical Animal Cosmetics Cyclic N-Oxides [AD] Female Injections, Intravenous Male Rabbits Publication Type JOURNAL ARTICLE ISSN 0002-8894 Country of Publication UNITED STATES CAS Registry/EC Number EC 3.1.3.1 (Alkaline Phosphatase) 0 (Cosmetics) 0 (Cyclic N-Oxides) 0 (Fatty Alcohols) 0 (Pyridines) 1121-30-8 (pyrithione) 13463-41-7 (zinc pyrithione) 151-41-7 (dodecyl sulfate) 67-68-5 (Dimethyl Sulfoxide) 7440-66-6 (Zinc) Date: Tue, 21 May 1996 04:29:02 -0700 From: Ed Anderson Subject: &r=10&f=G&key=80194316 Record from database: MEDLINE Title Acute toxicity of Zinc pyrithione to human skin cells in vitro. Author Priestley GC, Brown JC Source Acta Derm Venereol, 60: 2, 1980, 145-48 Abstract Zinc pyrithione introduced into cultures of rapidly proliferating NCTC 2544 human skin epithelial cells and normal human skin fibroblasts had a rapid cytotoxic effect even at very low concentrations (0.1-0.5 microgram/ml); there was no dose-dependent suppression of cell proliferation and no apparent interference with mitosis. Sodium pyrithione had a similar effect. Zinc oxide and zinc sulphate were at least 100 times better tolerated than zinc pyrithione, but no stimulatory effect on cell growth was detected with low concentrations of either compound. These results suggest that zinc pyrithione's action against dandruff is more likely to arise from a non-specific toxicity for epidermal cells than by an anti-mitotic effect or by remedying a local zinc deficiency. Language of Publication English Unique Identifier 80194316 MeSH Heading (Major) Pyridines [*PD] Skin [*DE] Zinc [*PD] MeSH Heading Cell Division [DE] Cells, Cultured Epithelium [DE] Fibroblasts [DE] Human Zinc Oxide [PD] Publication Type JOURNAL ARTICLE ISSN 0001-5555 Country of Publication SWEDEN CAS Registry/EC Number 0 (Pyridines) 1314-13-2 (Zinc Oxide) 13463-41-7 (zinc pyrithione) 7440-66-6 (Zinc) From MELVYL@UCCMVSA.UCOP.EDU Fri Feb 7 13:16:42 1997 Date: Mon, 11 Nov 96 22:55:10 PST From: Melvyl System Subject: (id: ACQ33498) MELVYL system mail result Search request: F TW PSORIASIS AND personal author FARBER Search result: 4 records at all libraries Display: DISPLAY 1. International Symposium on Psoriasis, 1st, Stanford University, 1971. Psoriasis; proceedings. Edited by Eugene M. Farber [and] Alvin J. Cox, in association with Paul H. Jacobs. Stanford, Calif., Distributed by Stanford University Press, 1971. UCD HealthSci WR205 I57 1971 UCLA Biomed W3 IN9223 1971 UCSF Library RL321 .I57 1971 Books SRLF D 0003781747 Type EXP SRLF for loan details. 2. International Symposium on Psoriasis, 2d, Stanford University, 1976. Psoriasis : proceedings of the second international symposium, Stanford University, 1976 / edited by Eugene M. Farber, Alvin J. Cox, in association with Paul H. Jacobs, M. Lexie Nall. 1st ed. New York : Yorke Medical Books, c1977. UCD HealthSci WR205 I57 1976 UCI MedCtr WR 205 I61 1976p UCI Sci Lib WR 205 I61 1976p Bar UCLA Biomed W3 IN9223 1976 UCSD Biomed WR 205 I616 1976p UCSF Library RL321 .I57 1976 Books 3. Psoriasis : proceedings of the fourth international symposium, Stanford University, July 6-11, 1986 / editors, Eugene M. Farber ... [et al.]. New York : Elsevier, c1987. UCD HealthSci WR205 P677 1986 UCI Sci Lib WR 205 P974 1986 Bar UCLA Biomed W3 IN9223 1986 UCSD Biomed WR 205 P973 1986 4. Psoriasis : proceedings of the Third International Symposium, Stanford University, 1981 / edited by Eugene M. Farber, Alvin J. Cox ; associate editor, Lexie Nall ; with the assistance of Paul H. Jacobs. New York, N.Y. : Grune and Stratton, c1982. UCD HealthSci WR205 P676 1982 UCI MedCtr WR 205 P974 1981 UCI Sci Lib WR 205 P974 1981 Bar UCLA Biomed W3 IN9223 1981 UCSD Biomed WR 205 P973 1981 Book Stacks UCSF Library RL321 .P676 1982 Books From MELVYL@UCCMVSA.UCOP.EDU Fri Feb 7 13:16:42 1997 Date: Mon, 11 Nov 96 22:57:37 PST From: Melvyl System Subject: (id: PAK33500) MELVYL system mail result Search request: F TW PSORIASIS AND personal author FARBER Search result: 4 records at all libraries Display: LONG 1. Author: International Symposium on Psoriasis, 1st, Stanford University, 1971. Title: Psoriasis; proceedings. Edited by Eugene M. Farber [and] Alvin J. Cox, in association with Paul H. Jacobs. Stanford, Calif., Distributed by Stanford University Press, 1971. Description: xii, 478 p. illus. 26 cm. Notes: Includes bibliographies. Subjects: Psoriasis -- Congresses. Other entries: Farber, Eugene M., 1917- ed. Cox, Alvin J., 1907- ed. Call numbers: UCD HealthSci WR205 I57 1971 UCLA Biomed W3 IN9223 1971 UCSF Library RL321 .I57 1971 Books SRLF D 0003781747 Type EXP SRLF for loan details. 2. Author: International Symposium on Psoriasis, 2d, Stanford University, 1976. Title: Psoriasis : proceedings of the second international symposium, Stanford University, 1976 / edited by Eugene M. Farber, Alvin J. Cox, in association with Paul H. Jacobs, M. Lexie Nall. 1st ed. New York : Yorke Medical Books, c1977. Description: xxxv, 487 p. : ill. ; 25 cm. Notes: Includes bibliographical references and index. Subjects: Psoriasis -- Congresses. Other entries: Farber, Eugene M., 1917- Cox, Alvin J., 1907- Call numbers: UCD HealthSci WR205 I57 1976 UCI MedCtr WR 205 I61 1976p UCI Sci Lib WR 205 I61 1976p Bar UCLA Biomed W3 IN9223 1976 UCSD Biomed WR 205 I616 1976p UCSF Library RL321 .I57 1976 Books 3. Title: Psoriasis : proceedings of the fourth international symposium, Stanford University, July 6-11, 1986 / editors, Eugene M. Farber ... [et al.]. New York : Elsevier, c1987. Description: xxxii, 574 p. : ill. ; 24 cm. Notes: "Fourth International Symposium on Psoriasis"--Pref. Includes bibliographies and indexes. Subjects: Psoriasis -- Congresses. Psoriasis -- Congresses. Other entries: Farber, Eugene M., 1917- International Symposium on Psoriasis (4th : 1986 : Stanford University) Call numbers: UCD HealthSci WR205 P677 1986 UCI Sci Lib WR 205 P974 1986 Bar UCLA Biomed W3 IN9223 1986 UCSD Biomed WR 205 P973 1986 4. Title: Psoriasis : proceedings of the Third International Symposium, Stanford University, 1981 / edited by Eugene M. Farber, Alvin J. Cox ; associate editor, Lexie Nall ; with the assistance of Paul H. Jacobs. New York, N.Y. : Grune and Stratton, c1982. Description: xxxvii, 530 p. : ill. ; 27 cm. Notes: Proceedings of the Third International Psoriasis Symposium. Includes bibliographies and indexes. Subjects: Psoriasis -- Congresses. Psoriasis -- Congresses. Other entries: Farber, Eugene M., 1917- Cox, Alvin J., 1907- International Psoriasis Symposium (3rd : 1981 : Stanford University) Call numbers: UCD HealthSci WR205 P676 1982 UCI MedCtr WR 205 P974 1981 UCI Sci Lib WR 205 P974 1981 Bar UCLA Biomed W3 IN9223 1981 UCSD Biomed WR 205 P973 1981 Book Stacks UCSF Library RL321 .P676 1982 Books