From MELVYL@UCCMVSA.UCOP.EDU Sat Nov  9 02:12:01 1996
Date: Fri, 08 Nov 96 21:36:06 PST
From: Melvyl System <MELVYL@UCCMVSA.UCOP.EDU>
To: medline@pinch.com
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Search request: F KW PSORIASIS AND BATH
Search result:  12 citations in the Medline database

Display:  9 ABS

9. Ortel B; Perl S; Kinaciyan T; Calzavara-Pinton PG; Honigsmann H.
     Comparison of narrow-band (311 nm) UVB and broad-band UVA after oral or
     bath-water 8-methoxypsoralen in the treatment of psoriasis.
   Journal of the American Academy of Dermatology, 1993 Nov, 29(5 Pt 1):736-40.
     Pub type:  Clinical Trial; Journal Article.
       (UI:  94043979)
     AT: UCSF  Library   W1 JO 2J Journals    1, 1979-.  Currently received.
         UCSF  Mt. Zion  Journals             v. 1, 1979-
         UCSF  SFGH      No call number Journals
                                              2, 1980-.  Currently received.
         (PE title:  Journal of the American Academy of Dermatology.)

Abstract: BACKGROUND: There is a disparity between the absorption spectrum of
    8-methoxypsoralen and the action spectrum for psoralen-sensitized erythema.
    In an action spectrum corrected for unsensitized reaction 313 and 365 nm
    have similar efficacies. OBJECTIVE: We evaluated the relative erythemogenic
    and antipsoriatic efficacy of narrow-band (311 nm) UVB with and without
    prior psoralen exposure. We also compared the effects of narrow-band UVB
    and broad-band UVA after oral and bath-water psoralen exposure. METHODS:
    Patients with psoriasis underwent half-side comparison studies. In one
    group the therapeutic efficacy of 311 nm UVB with and without oral psoralen
    was assessed. The second group received UVA and 311 nm UVB after oral
    psoralen. The third group was exposed to both radiation sources after
    bath-water exposure. RESULTS: The erythemogenic, pigmentogenic, and
    therapeutic efficacy of 311 nm was increased by oral psoralen. With
    systemic 8-methoxypsoralen, UVA was comparable to 311 nm UVB. After
    bath-water exposure, 311 nm was clearly superior to broad-band UVA.
    CONCLUSION: The efficacy of narrow-band 311 nm UVB can be enhanced by
    psoralen. Narrow-band 311 nm UVB is also effective after psoralen
    bath-water delivery.